Captain Ray Holt (Andre Braugher) takes over Brooklyn's 99th precinct, which includes Detective Jake Peralta (Andy Samberg), a talented but carefree detective who's used to doing whatever he wants. The other employees of the 99th precinct include Detective Amy Santiago (Melissa Fumero), Jake's over achieving and competitive partner; Detective Rosa Diaz (Stephanie Beatriz), a tough and kept to herself coworker; Detective Charles Boyle (Joe Lo Truglio), Jake's best friend who also has crush on Rosa; Detective Sergeant Terry Jeffords (Terry Crews), was recently taken off the field after the birth of his twin girls; and Gina Linetti (Chelsea Peretti), the precinct's sarcastic administrator.

Mourning the death of his brother, Jack's friend Iris invites him to her father's cottage for some alone time to recuperate. Unbeknownst to either of them, Iris's sister Hannah is also staying at their father's cottage recovering from her recent break-up. One entire bottle of tequila later, Jack and Hannah wake up to find Iris at the door. They each have secrets that they're tying to keep and they each have feelings that they're trying to sort out.

A.C.O.D. follows a seemingly well-adjusted Adult Child of Divorce (Adam Scott) who is forced to revisit the chaos of his parents' (Catherine O'Hara and Richard Jenkins) bitter divorce all over again after his younger brother (Clark Duke) decides to get married.

Nate moves to L.A. to track down Cristabel, the woman he's been in love with since childhood, only to discover that his plan to woo her only has one hurdle to overcome: what to do with June, Cristabel's ever-present, not-so-hot best friend? What's even more complicating is Nate's growing feelings for June, whose true beauty starts to emerge.