Four best friends start high school. Each one is unique and likes their own thing. When Meredith, the most popular girl, sees this she automatically knows they are trouble. Eventually though Cloe joins the soccer team and hangs out with them, Sasha joins the cheer leading squad and hangs out with the cheerleaders, Jade is part of the math club so she hangs out with them, and Yasmin is left all alone. After years of not talking to each other Jade and Yasmin speak a few words in the restroom but Yasmin doesn't have the courage to tell Jade she misses her. Then the four girls are reunited when they are sent to detention for causing a food fight. After the girls are reunited they find out they are not invited to a huge party given by Meredith Then Cloe finds out that her mom got a job serving food at the party. They are forced to work for Meredith Then at the party Meredith decides to expose Yasmins secret which is her dancing and singing with a face mask...

Veronica mingles with Heather I, II and III to be as popular as them, even though she hates them. She hates them enough to wish they were dead, though she would never want to be their cause of death. When she starts dating Jason Dean, however, she finds herself involved in the murders of most of her enemies, covered up as suicides.

Massie Block is the leader of a small group of privileged schoolgirls who arrogantly call themselves 'The Pretty Committee'. These so-called pre-teen 'mean girls' (cynical, egotistical, selfish and narcissistic females) and their clique are respected and feared in their middle school as well as their upper class Rhode Island suburban neighborhood. But Massie's life takes an unexpected turn when her parents friends, a lower-middle class family with a self-assured daughter named Claire move into the Block's guest house and Claire threatens to undermine the superficial Massie's position of the clique.