Pongo and Perdita have a litter of 15 puppies. Cruella De Vil takes a fancy to the pups, and wants to get hold of them, as well as more pups, to make herself a lovely dalmatian skin coat... Cruella hires some thugs to kidnap the pups and hold them at her mansion. Will Pongo and Perdita find them in time ?

Fashion designer Anita and computer-game writer Roger meet, fall in love and marry along with their dalmatians Perdita and Pongo. But the proud dogs' puppies are kidnapped by Anita's boss Cruella De Vil, who is stealing young dalmatians to make the coat she has set her heart on. Enlisting the help of the British animal kingdom, Pongo and Perdita set out to find and rescue all ninety-nine pups from their fearsome captors, Jasper and Horace.

Roger, Anita and their canine clan are packing for the big move to Dalmatian Plantation, a home in the country with plenty of room for the 101 pups and far from the clutches of Cruella DeVil. The feistiest pup, Patch, feels lost in a sea of spots and longs to be a one-of-a-kind wonderdog like his TV hero, Thunderbolt. While watching the Thunderbolt Adventure Hour, Patch hears about a chance to appear on the show while it's filming in London. However, the family move will interfere with Patch's...