Chicago DEA agent John Hatcher has just returned from Colombia, where his partner was killed in the line of duty by a drug dealer who has since been taken down. As a result of his partner's death, John has decided to retire, but his retirement may not be permanent. On the next day, after reuniting with his sister Melissa and Melissa's daughter Tracy, John gets into a shootout against a Jamaican drug kingpin known as Screwface, taking down some of Screwface's men. John brings himself out of retirement when Screwface retaliates by attempting to kill Melissa and Tracy. After the shooting, John is reunited with two old friends - a local high school football coach named Max, and a Jamaican Chicago cop named Charles. John and Max set out to hunt Screwface down, only to discover that Screwface has gone back to Jamaica. John and Max take Charles with them to Jamaica for an all out war against Screwface and his drug empire.

Sean Vetter and Demetrius Hicks are members of the DEA who are fighting an ongoing drug war on the California/Mexico border, they are most successful at it because of their edge of growing up on the street and being thugs converted to cops. The DEA busts one of the major players by the name of "Memo" Lucero and imprison him in the United States but then a major player named Diablo then takes over the business and now he is now the major player targeted by Vetter and his team. But when Vetter's wife is killed in a botched hit organized by Diablo, he seeks revenge against those responsible and in the process has to seek help from the imprisoned Lucero in order to catch Diablo. But in the process, Vetter and Hicks have to fight their way up the chain to get to Diablo but it's easier said than done when all Vetter can focus on is revenge...