Are all relationships based on lies? Jake Bianski runs a fish market in north Boston, surrounded by Italians. For years, he's carried a torch for Isabella, an ex-girlfriend now married with three children and no interest in Jake. Yet, he tells everyone she's his girlfriend, including Marisa, a veterinarian his employees set him up with at the Italian singles club. She's interested in him until he tells her about his girlfriend, then he's persistent in asking her to be his friend. As the friendship bumps along, Jake realizes that reality may be better than fantasy, but what if Isabella changes her mind about Jake, and what if it comes out that Marisa, like Jake, isn't Italian?

Dr Miles Bennell returns his small town practice to find several of his patients suffering the paranoid delusion that their friends or relatives are impostors. He is initially skeptical, especially when the alleged dopplegängers are able to answer detailed questions about their victim's lives, but he is eventually persuaded that something odd has happened and determines to find out what is causing this phenomenon. This film can be seen as a paranoid 1950s warning against those Damn Commies or, conversely, as a metaphor for the tyranny of McCarthyism (or the totalitarian system of Your Choice) and has a pro- and epilogue that was forced upon Siegel by the studio to lighten the tone.

Anna and Max are a young creative couple living together. Anna is a journalist and Max is an intriguing and slightly eccentric artist. Their idyllic relationship starts coming apart when Max develops some strange symptoms. He hears voices and sees visions which force him to withdraw from society and to mistrust Anna. When Anna discovers the cause of the problem it may be too late.