The continuing saga of Hannibal Lecter, the murdering cannibal. He is presently in Italy and works as a curator at a museum. Clarice Starling, the FBI agent whom he aided to apprehend a serial killer, was placed in charge of an operation but when one of her men botches it, she's called to the mat by the Bureau. One high ranking official, Paul Krendler has it in for her. But she gets a reprieve because Mason Verger, one of Lecter's victims who is looking to get back at Lecter for what Lecter did to him, wants to use Starling to lure him out. When Lecter sends her a note she learns that he's in Italy so she asks the police to keep an eye out for him. But a corrupt policeman who wants to get the reward that Verger placed on him, tells Verger where he is. But they fail to get him. Later Verger decides to frame Starling which makes Lecter return to the States. And the race to get Lecter begins.

Brigitte's on the run from Bailey Downs, and she tries to prevent what happened to her sister, Ginger, from happening to her by shooting up with monkshood. Eventually she collapses and the police that find assume the monkshood is an illegal drug, and she is sent to rehab. She is deprived of the only thing that will stop her from turning into a beast and killing everyone and everything in her way. She meets a girl who is quiet and not well-liked, and much like herself, by the name of Ghost that helps her deal with her new problem and to escape the werewolf curse.