Shadow of the Vampire is a film about the making of a German all time classic silent horror-movie from 1922 called Nosferatu-Eine Symphonie des Grauens (Nosferatu-a Symphony of Horror). The production of Nosferatu had to deal with a lot of strange things (some crew members disappeared, some died). This movie focuses on the difficult relationship between Murnau, the director, and Schreck, the lead actor.

Wisbourg, Germany based estate agent Knock dispatches his associate, Hutter, to Count Orlok's castle in Transylvania as the Count wants to purchase an isolated house in Wisbourg. They plan on selling him the one across the way from Hutter's own home. Hutter leaves his innocent wife, Ellen, with some friends while he is away. Hutter's trek is an unusual one, with many locals not wanting to take him near the castle where strange events have been occurring. Once at the castle, Hutter does manage to...