Dawn grows up in the shadow of a nuclear power plant. In high school, while her biology class studies evolution, she realizes she may have a hidden curse, an "adaptation." She lives with her mom, step-father, and hard-edged step-brother. She likes Tobey, a guy at school, and he likes her. She takes a pledge to remain chaste until marriage, so they date in groups, watch G-rated films, and don't kiss, but the power of teen hormones is great, so temptation beckons. Dawn has an admirer in Ryan, and...

Ten years after the first American Pie movie, three new hapless virgins discover the Bible hidden in the school library at East Great Falls High. Unfortunately for them, the book is ruined, and with incomplete advice, the Bible leads them on a hilarious journey to lose their virginity.