After nearly four decades together, Ben (John Lithgow) and George (Alfred Molina) finally tie the knot in an idyllic wedding ceremony in lower Manhattan. But when George loses his job soon after, the couple must sell their apartment and - victims of the relentless New York City real estate market - temporarily live apart until they can find an affordable new home. While George moves in with two cops (Cheyenne Jackson and Manny Perez) who live down stairs, Ben lands in Brooklyn with his nephew (Darren Burrows), his wife (Marisa Tomei), and their temperamental teenage son (Charlie Tahan), with whom Ben shares a bunk bed. While struggling with the pain of separation, Ben and George are further challenged by the intergenerational tensions and capricious family dynamics of their new living arrangements.

An aging, out-of-work actress accepts one last job, though the consequences of her decision affect her in ways she didn't consider.

In the near future or an alternate reality, there are memory detectives, people who have the ability to enter other peoples' electronically aided memories. They often are used to resolve psychological conflicts, and sometimes to exonerate someone from a crime. John was at one time the top in this field but he has been recovering from the death of his wife, and a stroke. To get back into work the head of the small firm he works for offers him what is supposed to be a simple job, getting 16 year old Anna to start eating again. However, the "simple job" turns into his most challenging.