Picking up immediately where Anaconda 3 left off, herpetologist Amanda Hayes finally learns her employer Murdoch's true colors when he hires a doctor to harvest a fresh supply of blood orchids to experiment with the regenerative nectar on a baby snake in order to seek treatment for his own terminal illness. Amanda is forced to secretly bring together another team of scientists whom face off against a heavily armed squad of Murdoch's men to steal the coveted orchids before the killer Anaconda hunts both parties down.

When most of the population of Earth is infected with a virus and transformed into flesh eaters and blood drinking creatures, a group of hunters led by Tao chases the vampire zombies to eliminate them. Six non-infected survivors try to find the exit of an abandoned hospital crowded with the infected creatures, and Tao and his group help them. Meanwhile, the military command is ready to bomb the area and wipe it from the map.

In 2006, in Red River, Tennessee, a teenager has frequent nightmares. Her mother reads an old letter from 1817 written by her ancestor, Lucy Bell. After a dispute of lands judged by the church, her husband John Bell is cursed by his opponent Kathe Batts, who has a fame of being a witch. From this moment on, an entity threatens John and her daughter Betsy Bell, attacking the girl during the nights. With the support of Betsy's school teacher Richard Powell, who tries to find rational explanations for the manifestation; her brother John Bell Jr.; and their friend James Johnston, who unsuccessfully tries to exorcize the entity from the house, the family does their best to protect Betsy in the haunted house.

In New York, the former NYPD detective Ben Carson is hired to work as night watch of the remains of the Mayflower Department Store that was partially destroyed by fire many years ago. Ben became alcoholic and was retired from the police force after killing a man in a shooting. His marriage was also destroyed and now he is living in the apartment of his younger sister Angie. However he has not been drinking for three months and sees the employment as a chance to rebuild his life. When he goes to the rounds in his first night, he finds that the mirrors are impeccably clean and his colleague explains that the former night watch was obsessed by the mirrors. After a couple of nights, Ben sees weird images in the mirrors, but due to the lack of credibility of his past, his ex-wife Amy believes he has hallucinations as a side effect of his medication. When Angie is found brutally murdered in her bathtub...

1938, Romania: at 70, a professor of language and philosophy, Dominic Matei, contemplates suicide: the love of his life is dead, and he remains unable to complete his life's work on the origins of language. Then, he's struck by lightning. After a slow recovery, he grows younger. He must now avoid Nazis, who want to study and experiment on him. Some years later, he meets a young woman who has her own passage through a lightning storm. Not only does Dominic find love again, but her new abilities hold the key to his research. Is the sweetness of life finally at hand?

An epic fresco depicting the reign (1593-1601) of Mihai Pätrascu (better known as "Mihai Viteazul" / "Michael the Brave"), the famous prince who united the three provinces: Transalpine Vallachia, Transylvania and Moldavia, into the country of Romania, at the end of the 16th century (1599-1601) against the opposition of the Ottoman and Austrian Empires, this movie features large scale battle scenes mixed with political intrigues, murderous treachery, and family drama.