John Howard Payne leaves home and begins a career in the theater. Despite encouragement from his mother and his sweetheart, Payne begins to lead a life of dissolute habits, and this soon leads to ruin and misery. In deep despair, he thinks of better days, and writes a song that later provides inspiration to several others in their own times of need.

Dr. Henry Jekyll experiments with scientific means of revealing the hidden, dark side of man and releases a murderer from within himself.

Buster is playing golf with Sybil when he gets knocked out. An escaped prisoner changes clothes with him. Buster goes to prison and learns that he is to be hanged. He changes clothes with a guard just as prisoner Roberts attacks all the guards.

A young man can only get the woman he loves if he becomes famous and manages to get his picture in the newspapers. He determines to let nothing stand in the way of his doing exactly that, and in the process winds up getting involved with a gang of criminals and a locomotive chase.

The comfortable and amiable Daniel Boone Brown, a resident of New York's water front, becomes the victim of a mad scientist's psychological experiments. For days, Dr. Ulrich Metz messes up Daniel's life, bringing on failing health, restless sleep, a nervous and irritable disposition, tardiness for work, and superstitions that cause worry and fear. Several months into the ordeal, one of Metz's minions, hired as Daniel's livery, feeds him a midnight snack of spring onions, lobster, Welsh rarebit and mince pie. We see the contents of his stomach causing pain and distress; then he has vivid and surreal nightmares. Will Metz succeed in driving Daniel to suicide?

Buster's handmade boat, The Damfino, is finished and is, of course, too large to get through the basement door. When he drives off with it in tow, the side of his house, then the whole thing, collapses. At the harbor he rides the boat out only to have it sink beneath him. The rest is a series of adventures he and his family have with the restored boat.

Roscoe flirts with a girl in the park. Later he takes his wife and mother-in-law to the movies only to see his flirtation showing on the screen.

A young woman has a peaceful existence, living near the sea and enjoying a romance with a simple, hard-working fisherman. But she finds herself in sudden danger when she happens upon the crew of a boat while they are ashore in the act of smuggling. She is abducted and forced aboard their boat. While the fisherman races to organize a rescue mission, the crew of the boat decides to seize her from the captain, in order to have their way with her.

Charlie is in boot camp in the "awkward squad." Once in France he gets no letters from home. He finally gets a package containing limburger cheese which requires a gas mask and which he throws over into the German trench. He goes "over the top" and captures thirteen Germans ("I surrounded them"), then volunteers to wander through the German lines disguised as a tree trunk. With the help of a French girl he captures the Kaiser and the Crown Prince and is given a statue and victory parade in New York and then ... fellow soldiers wake him from his dream.

Cartoonist Winsor McCay agrees to create a large set of drawings that will be photographed and made into a motion picture. The job requires plenty of drawing supplies, and the cartoonist must also overcome some mishaps caused by an assistant. Finally, the work is done, and everyone can see the resulting animated picture.