In Bangkok, in a low-budget hotel called "Heaven", the fate of four guests are interconnected due to a theft in a room: Sean, a paranoid English drug dealer, that is dealing with a powerful local drug lord; the also British psychologist Rosa, who is grieving the loss of her son and making a research with poor children in Thailand; a seriously wounded killer, hired to kill the mobster; and Wit, a thirteen years old abused bellboy, that steals the guests. In the end, we see that it is almost impossible to control life, and sometimes, a subtle incident may lead to fatality.

Alex Bernier (Ledger) is a member of an arcane order of priests known as Carolingians. When the head of the order dies, Alex is sent to Rome to investigate mysterious circumstances surrounding the death. The body bears strange marks on the chest which may or may not be the sign of a Sin Eater (Furmann), a renegade who offers absolution, last rites and therefore a path to heaven outside the jurisdiction of the church. Alex enlists the aid of his old comrade Father Thomas (Addy) and of a troubled artist (Sossamon) upon whom he once performed an exorcism. He soon finds himself plunged into a mystery only to find himself at the heart of it.

When a storm washes a canoe bearing an infant boy ashore upon a small South Pacific island, he is at first well-received as a gift from the heavens...