Desperately losing his mind while searching for a new pair of shoes, an old man and his trusty Walker wander the City of Rott, saturated with thousands of rotting zombies, driven to feed the blood-hungry worms residing in their skulls.

A villain named McCreep steals the Smurfs' magic flute, an instrument that makes people dance wildly, and uses it to rob them. The Smurf King sends out Peewit to track down the thief and retrieve the flute. Now Johan and Pirlouit must get it back at all costs, so they head to the magical kingdom of Smurfs to ask for their help.

The world has become a vast conglomerate of islands of varying size and shape. This babbling universe is mainly populated with ruthless rogues, surly peasants and illiterate, petty lords. Their main concerns revolve around two fundamental rules: Eat and don't get eaten. For this new world has become infested with a terrible plague: omnipresent, monstrously famished, mutant creatures, are wreaking havoc - They are known as the Dragons. Gwizdo and Lian-Chu are two dragon hunters, but are a long way from being among the best. Their only real talents: the size of the hulking brute with the heart of gold, Lian-Chu, and Gwizdo's talent for scams of all and any shape or form. Their sole ambition: to buy a little farm where they can relax and raise mussels, a creature that is a lot less unpleasant and difficult to hunt down than dragons. A few islands away rises the fortress of Lord Arnold...