In 1959, an alien experiment crashes to earth and infects a fraternity member. They freeze the body, but in the modern day, two geeks pledging a fraternity accidentally thaw the corpse, which proceeds to infect the campus with parasites that transform their hosts into killer zombies.

While kung fu warriors and otherworldly spirits battle over the fate of two women, Russell's swaggering idiot manages to knock himself out or underestimate the forces he's dealing with. Jack Burton, a tough-talking, wisecracking truck driver whose hum-drum life on the road takes a sudden supernatural tailspin when his best friend's fiancee is kidnapped. Speeding to the rescue, Jack finds himself deep beneath San Francisco's Chinatown, in a murky, creature-filled world ruled by Lo Pan, a 2000-year-old magician who mercilessly presides over an empire of spirits. Dodging demons and facing baffling terrors, Jack battles his way through Lo Pan's dark domain in a full-throttle, action-riddled ride to rescue the girl.