What is a mosquito's nature? A large man enters his flat; a mosquito in top hat with valise follows, entering through the window above door. The man goes to sleep; the mosquito lands next to him, opens the valise, and takes out a grinding wheel to sharpen his proboscis. Methodically, the mosquito gets one, two, then three drinks as the man tosses, slaps, turns, covers himself, and rubs the wounds. After a fourth drink, the mosquito is so full he can barely right himself. Still he has more. Bloated, he can only hover above the sleeping man's face. Suspense builds: can he launch? He's atop his victim's nose. He jettisons his valise. Will he now be light enough to escape?

When Pollyanna is orphaned, she is sent to live with her crotchety Aunt Polly. Pollyanna discovers that many of the people in her aunt's New England home town are as ill-tempered as her aunt. But Pollyanna's incurable optimism - exemplified by her "glad game," in which she looks for the bright side of every situation - bring a change to the staid old community.

Buster is thrown off a train near an amusement park. There he gets a job in a shooting gallery run by the Blinking Buzzards mob. Ordered to kill a businessman, he winds up protecting the man and his daughter by outfitting their home with trick devices.

Buster is a bank clerk. Overturned glue gets everything, mostly the money, stuck to everything else. When robbers show up he can't "stick 'em up" because his hands are stuck in his pockets. The robbers' hideout is a haunted house designed to scare off police.

Ojo and Unc Nunkie are out of food, so they decide to journey to the Emerald City where they will never starve. Along the way, they meet Mewel, a waif and stray (mule) who leads them to Dr. Pipt, who has been stirring the powder of life for nine years. Ojo adds plenty of brains to Margolotte's Patchwork servant before she is brought to life with the powder. When Scraps does come to life, she accidentally knocks the liquid of petrifaction upon Unc Nunkie, Margolotte, and Danx (daughter Jesseva's boyfriend). So all go on separate journeys to find the ingredients to the antidote. (Of course Jesseva has Danx shrunken to take with her, which causes trouble with Jinjur.) Of course, no one ever told Ojo that some of the ingredients were illegal to obtain...

A young couple attempts to elope, with the bride's irate father in hot pursuit. The train stops briefly and the young man dashes off to find a minister, but before he can get himself and the minister onto the train, it leaves, carrying his bride-to- be away. Now the young man, minister in tow, pursues his bride while her father and a horde of lawmen pursue them both.

Roscoe tries to dump his wife so he can enjoy the beach attractions. Buster arrives with Alice who is taken away from him by Al who loses her to Roscoe. Bathing beauties and Keystone Kops abound.

Winsor Z. McCay bets another cartoonist that he can animate a dinosaur. So he draws a big friendly herbivore called Gertie. Then he get into his own picture. Gertie walks through the picture, eats a tree, meets her creator, and takes him carefully on her back for a ride.