Loosely connected stories capture a week in L.A. in 1983, featuring movie executives, rock stars, a vampire and other morally challenged characters in adventures laced with sex, drugs and violence.

In 1941, New York intellectual playwright Barton Fink comes to Hollywood to write a Wallace Beery wrestling picture. Staying in the eerie Hotel Earle, Barton develops severe writer's block. His neighbor, jovial insurance salesman Charlie Meadows, tries to help, but Barton continues to struggle as a bizarre sequence of events distracts him even further from his task.

In China, the poor worker Tietou repairs tractors and misses his sweetheart Xiu Xiu, back in Japan, she having never sent any news to her family or him. While illegally emigrating to Japan, Tietou loses his Chinese documents and so cannot return to his country. He is welcomed by his countrymen who lodge and work in Shinjuku where they also help him to find illegal work. While running from a police raid through the sewage system where Chinese are illegally working, Tietou saves Inspector Kitano from drowning in the dirty water. Later, after an incident with his cousin, Joe, and a Taiwan gang, Tietou saves the powerful Yakuza boss Toshinari Eguchi. He is the husband of Xiu Xiu, who is now called Yuko and are parents of a little daughter. The mobster offers a dirty job to Tietou; in retribution, he promises to deliver the quarter dominated by the Taiwan gang to him. Tietou becomes the boss of the Chinese illegal immigrants...