Mischa and Hannibal, baby brother and sister, are inseparable; it is their love for each other that ties their bond. Their companionship is forever binding, until, with their family, while hiding from the Nazi war machine a twisted set of circumstance sets the pace for a most vicious attack on the future of one Hannibal Lecter for the sworn vengeance for the brutal killing of his baby sister. Years later, we find Hannibal, the teenager, setting up in Paris, and living with his aunt Lady Murasaki Shikibu and studying at medical school here he finds his forte. Still searching for his sister's murderers, still bitter and still ever hopeful of satisfying his desire for retribution. This chance arrives, and soon we are to learn that for a pound of flesh lost a pound of flesh must be repaid. This is the horrific tale of justice and honor, a young man's growing pains that will have the guilty paying with more than just flesh and bone...

While driving through the New Mexico Desert during a rainy night, the college students Jim Halsey and his girlfriend Grace Andrews give a ride to the hitchhiker John Ryder. While in their car, the stranger proves to be a psychopath threatening the young couple with a knife, but Jim succeeds to throw him out of the car on the road. On the next morning, the young couple sees John in another car with a family, and while trying to advise the driver that the man is dangerous, they have an accident. While walking on the road, they find the whole family stabbed in the car, and John sees that the driver is still alive. He drives to a restaurant seeking for help, but the police blame Jim and Grace to the murder and send them to the police station. However, John kills the policemen and pursues the couple, playing a tragic and violent mouse and cat game with Grace and Jim.

Cedric the Entertainer plays Jake, a seemingly regular guy who has no idea who he is after being hit over the head by mysterious assailants; when he finds himself entangled in a government conspiracy, Jake and his pursuers become convinced that he is an undercover agent.

Mob boss Primo Sparazza has taken out a hefty contract on Buddy "Aces" Israel, a sleazy magician who has agreed to turn state's evidence against the Vegas mob. The FBI, sensing a chance to use this small-time con to bring down big-target Sparazza, places Aces into protective custody-under the supervision of two agents dispatched to Aces' Lake Tahoe hideout. When the word of the price on Aces' head spreads into the community of ex-cons and cons-to-be, it entices bounty hunters, thugs-for-hire, deadly vixens and double-crossing mobsters to join in the hunt. With all eyes on Tahoe, this rogues' gallery collides in a comic race to hit the jackpot and rub out Aces.