In Cayman Island, the daughter of a powerful man - Andrea - and the fisherman Shy are in a deep but secret love, hidden from Andrea's parents. When Andrea's father sails in a fish-trip, they have a night of love at Andrea's home; however they sleep and are surprised by the arrival of her family in the morning. Later, Andrea's brother Hammer throws acid on the face of Shy and spends four months in prison. In Miami, the dirty businessman Carl Ridley is chased by Federal agents and escapes with his teenage daughter Pippa to Cayman Island trying to reach his lawyer Mr. Allen. Pippa meets the small time thief Fritz sleeping in her room and he invites her to go a party. Before leaving the condo, Fritz sees Carl counting lots of money. Fritz owes money to the dangerous drug dealer Richie Rich and tells him about the fortune Carl has. Along a Friday 13th night, their lives entwine in a chain of tragic events.

After leaving the prison, the dwarf criminal Calvin Sims joins to his moron brother Percy to steal an expensive huge diamond in a jewelry for the mobster Walken. They are chased by the police, and Calvin hides the stone in the purse of the executive Vanessa Edwards, whose husband Darryl Edwards wants to have a baby. Percy convinces Calvin to dress like a baby and be left in front of the Edwards's house to get inside the house and retrieve the diamond. Darryl and Vanessa keep Calvin for the weekend and decide to adopt him, while Walken threatens Darryl to get the stone back.

While investigating a call in an abandoned house, Officer Frank Williams and a rookie find a woman brutally blinded, but they are attacked by a huge psychopath with an ax; the rookie is killed and Frank shots the criminal in the head, but has a severed arm. Four years later, the mutilated Frank is relocated, working as a guard in the County Detention Center. Frank goes with some delinquents to the Blackwell Hotel, an abandoned place since a fire burnt the last two floors, with the purpose of cleaning the location, preparing it to work as a shelter for homeless; in return, the criminals will have their sentences reduced. During the night, the inmate Kira that has some Christian tattoos in her body is kidnapped by the deranged serial-killer Kane that collect the eyes of his victims, while the rest of the group is attacked by the psychopath with his ax.

In Baltimore, the troublemaker and street dancer Tyler Gage lives with his foster parents in an Afro-American lower class neighborhood. His best friends are Mac Carter and his little brother Skinny Carter and they used to hang around together, going to parties and stealing cars. After being expelled of a party, the trio breaks in the Maryland School of Arts and commits vandalism, destroying the stage. Tyler is arrested and sentenced to 200 hours of community service in the school and Director Gordon assigns him to help the janitor cleaning the place. One afternoon, the ballet dancer Nora Clark sees Tyler dancing in the parking area and when her partner Andrew has a strain and Tyler offers to help her in the choreography, she accepts the offer; they rehearsal and become close to each other while Tyler becomes friend of the students Miles Darby and Lucy Avila. When Andrew returns, Tyler that is known for quitting everything he starts gives up dancing and leaves Nora alone...

In New York, when the shy and lonely project manager of a design firm Matt Saunders meets Jenny Johnson in the subway, he invites her to date and have dinner with him. Jenny immediately falls in love for him, they have sex and she discloses her true identity to him, telling that she is the powerful superhero G-Girl. After meeting his co-worker and friend Hannah Lewis, the needy Jenny becomes jealous, controlling and manipulative, and Matt follows the advice of his best friend Vaughn Haige and dumps her, breaking her heart. Jenny turns Matt's life into hell, while he has a romance with Hannah. However, the archenemy of G-Girl and former high school sweetheart of Jenny, Professor Bedlam, proposes Matt to lure Jenny to strip her superpowers.