Jigsaw and his young apprentice, Amanda, are dead. But the grisly games continue. 5 supposed strangers find themselves in the midst of the big game, and believe they are in a survival of the fittest competition. Via his now infamous video linked doll, Jigsaw conveys the message that they should ignore there instincts, and ignore his advice at their peril. Meanwhile, agent Strahm wants to prove that Hoffman is an apprentice to Jigsaw, and pursues him as he continues his twisted games. What Strahm does not realize is that Hoffman is testing him all along, and must pass his test in order to stay alive.

Three years ago, NYPD detective Max Payne's wife and baby were murdered. Max gets himself transferred to the cold case office where he can continue searching for the killer who got away. He's a loner, but two people reach out to him during a fateful week: Alex, his ex-partner who may have found a clue, and BB, the security chief at the pharmaceutical company where Max's wife worked. Meanwhile, bodies are piling up, some as a result of a drug on the street that is highly addictive and, for many who take it, brings hideous hallucinations. When one of the bodies is a woman Payne was the last to see alive, her sister comes looking for him armed to the teeth; Max must move fast.

Samir Horn is a former soldier, a devout Moslem, and U.S. citizen in the Middle East selling bomb detonators to Islamic radicals. He joins their cause as both the FBI and a rogue CIA agent track him. Horn escapes a Yemeni prison, goes underground in France where he proves his abilities, and is sent to the United States to choreograph a simultaneous and multiple terror attack. Will the intelligence agencies talk to each other, and can Horn be stopped?

Fox Mulder and Dana Scully both worked at the FBI as partners, a bond between them that led to their becoming lovers. But now they're out of the FBI and have begun new careers. Scully works as a staff physician at a Catholic hospital. Her focus these days is on a young boy with an incurable brain disease. Administration wants to give up on him. Scully, who feels a special bond with the boy, does not. Meanwhile, Mulder's focus is on clipping newspaper articles, throwing pencils into his ceiling and writing about the paranormal. Scully and Mulder are brought together as partners again when a special case requires Mulder's expertise and Scully is prevailed upon to convince him to help. The case involves a pedophile priest who claims he is having psychic visions regarding the whereabouts of a missing FBI agent.

Michael Dixon is a seasoned agent working linewatch on the US/Mexico Border. Well respected by his peers at US Border Patrol, and well loved by his family (wife Angela and 5 year old daughter Emily), Michael's world is suddenly threatened by secrets from his past. Michael was not always the respectable family man he now has become - he was a vicious Los Angeles gang member who turned his back on the gang and his own brutal ways. But no one can quit the gang, so when a chance encounter leads the gang to Michael in New Mexico, Michael is forced to find a way to protect his family, even if it means helping the psychotic gang leader Drake smuggle a truckload of drugs across the border.

Brandi is a hard-partying, overworked, nursing assistant desperate for a promotion at the retirement home where she works. After a night of drug-binging and partying, she accidentally hits a certain Thomas Bardo a deadbeat and recently evicted man who gets stuck in the windshield of her car. Not wanting to call for help since she is driving under the influence, Brandi, chooses not to get Thomas medical help and instead drives home and leaves him clinging to his life in the windshield of her car. While Brandi frantically tries to decide what she is going to do, Thomas, tries to free himself knowing his time is running out.