In 1958, in New York City, the upper class Diane Arbus is a frustrated and lonely woman with a conventional marriage with two daughters. Her husband is a photographer sponsored by the wealthy parents of Diane, and she works as his assistant. When Lionel Sweeney, a mysterious man with hypertrichosis (a.k.a. werewolf syndrome, a disease that causes excessive body hair), comes to live in the apartment in the upper floor, Diane feels a great attraction for him and is introduced to the world of freaks and marginalized people, falling in love with Lionel.

A mother and her daughter, a mother and her son, and a man living with one and attracted to the other. Miro, a teen from Sarajevo, lives near King's Cross with his mother; he's nimble, able to run across roofs, so his uncle hires him to break into office skylights, so the uncle can boost computers. Twice they steal from Will's architectural firm, so Will stakes it out at night. He follows Miro home and returns the next day and meets Miro's mother, Amira. At home, Will's relationship with Liv is strained - he feels outside Liv and her daughter Bea's circle. The stakeout and Amira's vulnerability are attractive alternatives to being at home. The police, too, watch Miro.

After the sudden death of her fiancé, Gray Wheeler finds comfort in the company of his friends: lighthearted and comic Sam, hyper-responsible Dennis, and, oddly enough, his old childhood buddy Fritz, an irresponsible playboy whom she'd previously pegged as one of the least reliable people in the world. As secrets about her supposedly perfect fiancé emerge, Gray comes to see new sides of the man she thought she knew, and at the same time, finds herself drawn to the last man she ever expected to fall for.

Innocent lives hang on the whim of an elusive psychopathic murderer whose strange riddles and impossible timelines force three people into a mission to end the game before one or all of them die.