In Chicago, the art dealer Brooke Meyers feels not appreciated and neglected by her immature boyfriend Gary Grobowski, who is partner of his two brothers in a tourism business, and decides to break-up with him to make Gary misses her. Gary misunderstands her true intention, both follows the wrong advices of family members and friends, beginning a war of sexes with no winner.

In Cayman Island, the daughter of a powerful man - Andrea - and the fisherman Shy are in a deep but secret love, hidden from Andrea's parents. When Andrea's father sails in a fish-trip, they have a night of love at Andrea's home; however they sleep and are surprised by the arrival of her family in the morning. Later, Andrea's brother Hammer throws acid on the face of Shy and spends four months in prison. In Miami, the dirty businessman Carl Ridley is chased by Federal agents and escapes with his teenage daughter Pippa to Cayman Island trying to reach his lawyer Mr. Allen. Pippa meets the small time thief Fritz sleeping in her room and he invites her to go a party. Before leaving the condo, Fritz sees Carl counting lots of money. Fritz owes money to the dangerous drug dealer Richie Rich and tells him about the fortune Carl has. Along a Friday 13th night, their lives entwine in a chain of tragic events.

In Ohio, Priscilla Chase is the VP of a company that works bringing new business to Cleveland. She has been married for more than ten years with Jack Chase, the biology teacher from the local public school. Priscilla is successful in her career but is frigid and has never reached an orgasm, hurting her frustrated husband. When Priscilla decides to buy a vibrator, Jack is seduced by his teenage student Kristen Taylor and recovers his self-esteem, working out, losing weight and dressing adequately. Priscilla has new sexual experiences and becomes closer to Wayne the Pool Guy, the constructor of swimming pools in her neighborhood since she was a child. The new relationships upgrade the personal and professional lives of Priscilla and Jack.

A calamity at Dante and Randall's shops sends them looking for new horizons - but they ultimately settle at Mooby's, a fictional fast-food restaurant. Free from his dead-end job (and lodged in a new one), Dante begins to break free of his rut, planning to move away with his clingy fiancé. Dante is ready to leave the horrors of minimum-wage New Jersey behind, but Randal - always the more hostile of the two - starts to become overwhelmed by his own rancor.

On September, 11th 2001, after the terrorist attack to the World Trade Center, the building collapses over the rescue team from the Port Authority Police Department. Will Jimeno and his sergeant John McLoughlin are found alive trapped under the wreckage while the rescue teams fight to save them.

In the 50's, in Louisiana, the smart populist, manipulative and wolf hick Willie Stark is elected governor with the support of the lower social classes. He joins a team composed of his bodyguard and friend Sugar Boy; the journalist from an aristocratic family Jack Burden; the lobbyist Tiny Duffy; and his mistress Sadie Burke, to face the opposition of the upper classes. When the influent Judge Irwin supports a group of politicians in their request of impeachment, Stark assigns Jack to find some dirtiness along the life of Irwin, leading to a tragedy in the end.

In Baltimore, the troublemaker and street dancer Tyler Gage lives with his foster parents in an Afro-American lower class neighborhood. His best friends are Mac Carter and his little brother Skinny Carter and they used to hang around together, going to parties and stealing cars. After being expelled of a party, the trio breaks in the Maryland School of Arts and commits vandalism, destroying the stage. Tyler is arrested and sentenced to 200 hours of community service in the school and Director Gordon assigns him to help the janitor cleaning the place. One afternoon, the ballet dancer Nora Clark sees Tyler dancing in the parking area and when her partner Andrew has a strain and Tyler offers to help her in the choreography, she accepts the offer; they rehearsal and become close to each other while Tyler becomes friend of the students Miles Darby and Lucy Avila. When Andrew returns, Tyler that is known for quitting everything he starts gives up dancing and leaves Nora alone...

Michael and Jenna, having been a couple for three years, want to get married and start a family. These plans seem to be well on their way when Jenna announces that she's pregnant. But Michael is worried that his life and his youth will over for good. At a wedding of a friend, he meets a free-spirited college co-ed, Kim, who opens his eyes and leads him on a dangerous path away from Jenna. Meanwhile, none of the relationships of the people surrounding Michael and Jenna are happy and stable. Michael's friend Izzy is unwilling to let go of his childhood sweetheart Arianna; Kenny is a handsome stud who fears commitment to his latest conquest Danielle; and Chris is a co-worker who is dominated by his neurotic and overbearing wife over raising their newborn son. Even Jenna's parents, Stephen and Anna, are experiencing problems in their long-suffering marriage.

In New York, when the shy and lonely project manager of a design firm Matt Saunders meets Jenny Johnson in the subway, he invites her to date and have dinner with him. Jenny immediately falls in love for him, they have sex and she discloses her true identity to him, telling that she is the powerful superhero G-Girl. After meeting his co-worker and friend Hannah Lewis, the needy Jenny becomes jealous, controlling and manipulative, and Matt follows the advice of his best friend Vaughn Haige and dumps her, breaking her heart. Jenny turns Matt's life into hell, while he has a romance with Hannah. However, the archenemy of G-Girl and former high school sweetheart of Jenny, Professor Bedlam, proposes Matt to lure Jenny to strip her superpowers.

In New York, the simple and naive just-graduated in journalism Andrea Sachs is hired to work as the second assistant of the powerful and sophisticated Miranda Priestly, the ruthless and merciless executive of the Runway fashion magazine. Andrea dreams to become a journalist and faces the opportunity as a temporary professional challenge. The first assistant Emily advises Andrea about the behavior and preferences of their cruel boss, and the stylist Nigel helps Andrea to dress more adequately for the environment. Andrea changes her attitude and behavior, affecting her private life and the relationship with her boyfriend Nate, her family and friends. In the end, Andrea learns that life is made of choices.

After a plane crash, a young therapist, Claire, is assigned by her mentor to counsel the flight's five survivors. When they share their recollections of the incident -- which some say include an explosion that the airline claims never happened -- Claire is intrigued by Eric, the most secretive of the passengers. Just as Claire's professional relationship with Eric -- despite her better judgment -- blossoms into a romance, the survivors begin to disappear mysteriously, one by one. Claire suspects that Eric may hold all the answers and becomes determined to uncover the truth, no matter the consequences.

Harvey Shine is in London for the weekend for his daughter's wedding. His work in New York preoccupies him: he writes music for ads, and he knows his boss is pushing him aside for younger talent. With family he's also on the sidelines - long divorced, his wife remarried, her husband closer to his daughter than he. His path crosses that of Kate Walker, unmarried, her life becoming that of a spinster, set up by friends on blind dates leading nowhere. After Harvey's no good terrible day, he chats Kate up at a Heathrow bar. She's not interested. Where can this conversation lead? Back at his daughter's reception, the step-father rises to give a toast.

Thinking Pulitzer Prize and hoping to bring down a President, D.C. political columnist Rachel Armstrong writes that the President ignored the findings of a covert CIA operative when ordering air strikes against Venezuela. Rachel names the agent, Erica Van Doren, a woman whose young daughter is in Rachel's son's class at school. The government moves quickly to force Rachel to name her source. She's jailed for contempt when she refuses. She won't change her mind, and the days add up. Chaos descends on Van Doren's life as well. First Amendment versus national security, marriage and motherhood versus separation. What's the value of a principle?

An armored car is robbed by three men. A passing police officer and one of the robbers exchange fire. The robber is Paulie. In a flashback we follow him and his closest friend, Brian, as they grow up together in South Boston. They're tough guys, thugs, doing jobs for the local boss and chaffing to do more. Paulie's the leader. Brian drinks too much and free bases, ignoring his wife and two young boys. Life-changing events lead him to try to go straight, look for work, take what comes his way, and go to A.A. meetings. He struggles. Paulie shows him the plans for the armored car job. Will they do it? "I am who I am," Brian tells his wife. Is crime his only skill?