Danika is a thirty-five year old overprotective mother with a beautiful family composed of her successful husband Randy, two sons - the teenager Kurt and the little Brian, and one teenager daughter - Lauren. Danika is disturbed and near a breakdown, having dark and terrifying nightmares and daydreams; distracted in her work and consequently committing mistakes; and under psychiatric treatment with Dr. Evelyn. Her problems originated when her husband cheated on her with the nanny of their children, breaking her confidence in him. The lack of attention caused by her disturbed mind leads her family into tragedy.

In Chicago, the art dealer Brooke Meyers feels not appreciated and neglected by her immature boyfriend Gary Grobowski, who is partner of his two brothers in a tourism business, and decides to break-up with him to make Gary misses her. Gary misunderstands her true intention, both follows the wrong advices of family members and friends, beginning a war of sexes with no winner.

In Cayman Island, the daughter of a powerful man - Andrea - and the fisherman Shy are in a deep but secret love, hidden from Andrea's parents. When Andrea's father sails in a fish-trip, they have a night of love at Andrea's home; however they sleep and are surprised by the arrival of her family in the morning. Later, Andrea's brother Hammer throws acid on the face of Shy and spends four months in prison. In Miami, the dirty businessman Carl Ridley is chased by Federal agents and escapes with his teenage daughter Pippa to Cayman Island trying to reach his lawyer Mr. Allen. Pippa meets the small time thief Fritz sleeping in her room and he invites her to go a party. Before leaving the condo, Fritz sees Carl counting lots of money. Fritz owes money to the dangerous drug dealer Richie Rich and tells him about the fortune Carl has. Along a Friday 13th night, their lives entwine in a chain of tragic events.

In Ohio, Priscilla Chase is the VP of a company that works bringing new business to Cleveland. She has been married for more than ten years with Jack Chase, the biology teacher from the local public school. Priscilla is successful in her career but is frigid and has never reached an orgasm, hurting her frustrated husband. When Priscilla decides to buy a vibrator, Jack is seduced by his teenage student Kristen Taylor and recovers his self-esteem, working out, losing weight and dressing adequately. Priscilla has new sexual experiences and becomes closer to Wayne the Pool Guy, the constructor of swimming pools in her neighborhood since she was a child. The new relationships upgrade the personal and professional lives of Priscilla and Jack.