After accidentally knocking her best friend off a roof, Alyce is haunted by guilt and delves into a brutal nightmare wonderland of sex, drugs and violence, her mind tearing itself apart along with anyone else who gets in her way.

Jack Samms' evening started normal enough. But then the mysterious masked stranger, known as Trick, pays him a visit. Within minutes, Jack is faced with a ticking clock after Trick reveals that Jack's estranged wife and her lover are buried in a wooden box - and will be out of oxygen in 75 minutes. With two cops hot on his trail, Jack must try to avoid being framed for his wife's murder while under Trick's constant watch. When a pay-off to Trick goes wrong, Jack must engage in a dangerous game of cat and mouse with the masked stranger in order to save his wife... and himself.

Dr. Hattori and her husband watch footage of brain surgery experiments with Manchurian, Russian and Japanese guinea pigs that had been found in the basement of a wrecked hospital. Out of the blue, there is a white light and when they look back, they see they children Ota Miyuki and Kaori staring at the light. Years later, Miyuki vanishes from the Tama Medical University Hospital and her sister Kaori, Miyuki's boyfriend Motojima and detective Hirasawa are seeking her. However, Miyuki and the teenagers Kazochi, Takumi, Hattori and Rieko have been submitted to a nightmarish experiment by Dr. Hattori and her team with tragic results.

The successful American writer and atheist Joseph Crone participates in a support group to accept the death of his beloved wife Sarah and their son Diogo. Joe befriends Sadie in one of the meetings and she helps him when he has a car accident. When Joe's estranged religious brother Samuel Crone (Michael Landes) tells him that their father is terminal, he travels to Barcelona to stay near the death bed of his father. Joe has visions of demons and with the number 11 and he finds that something evil will happen with Samuel and him on 11 November 2011.

In the early 70's, Commander Nathan Walker, Captain Ben Anderson and Lieutenant Colonel John Grey are assigned in a secret mission to the Moon to protect the USA from USSR using detectors. Nathan and Ben land on the Moon in the Liberty module while John stays in orbit in the module Freedom. They collect rock samples and bring them to the Liberty. They also find footprints and the body of a Soviet cosmonaut on the moon. Soon they hear weird noises and they find that they are not alone in the satellite.

In Spain, the former Nazi doctor Klaus tries to commit suicide jumping off the roof of his manor. However, he survives with the entire body paralyzed and dependable of an iron lung with glass sides. His wife Griselda decides to hire a nurse since she does not bear the situation. Klaus asks Griselda to hire Angelo, a mysterious teenager that appears in their house. Angelo befriends Klaus' daughter Rena and sooner it is shown that Klaus was a pedophile that loved to feel the fear of death in young boys before abusing and killing them. Further, Angelo is a disturbed and totally insane victim of his experiments that intends to follow the insanities described in Klaus' diary and incorporate his personality.

Samantha Sherwood has worked with the well-known director Jonathan Stryker on all his major films. She naturally assumes she has been given the title role in his latest venture, "Audra". He tells her that she nn needs to do some background research on the part, so arranges to have her committed to an asylum (as Audra is a former psychiatric patient). She goes along with this, not realising that he intends to leave her there indefinitely and audition six young women of various professions for the part instead. She finally manages to escape, and returns to the spooky old mansion where the auditions are taking place. But who is causing the disappearances of the young hopefuls?? Is it Samantha? Stryker? Or is one of the actresses willing to kill for the coveted part?? Just who is the killer behind the old-hag mask???