A businessman sinks $200 million into a special project to help fight brain cancer. As part of this project, medical biologist Susan McAlester rather naughtily figures out a way to genetically enlarge shark brains, so that cancer-battling enzymes can be harvested. However, the shark subjects become super smart and decide they don't much like being cooped up in pens and being stabbed with hypodermics, so they figure a way to break out and make for the open sea...

Hannah goes back to her hometown (Gatlin) to find out who her mother is, but on the way she picks up a strange man who fore-shadows her life with a passage from the bible. When she gets there she wakes up Isaac from a coma he has been in for 19 years. Isaac is awake and wants to fulfill the final prophecy.

Gabriel returns to Earth to prevent the birth of a child conceived by one of his kind (the Angel Daniel) and one of God's "monkeys" (a human woman - Valerie). The coming of this child has been prophecised by a monk, Thomas. When the Angel Daniel kills members of Gabriel's army of angels, Gabriel instead employs the assistance of a teenage girl (Izzy) who has just committed suicide. Gabriel keeps her alive to assist him in his war against Daniel and the other angels which climaxes in a battle in Eden.

On Halloween in 1963, Michael Myers murdered his sister, Judith. In 1978, he broke out to kill his other sister, Laurie Strode. He killed all of her friends, but she escaped. A few years later, she faked her death so he couldn't find her. But now, in 1998, Michael has returned and found all the papers he needs to find her. He tracks her down to a private school where she has gone under a new name with her son, John. And now, Laurie must do what she should have done a long time ago and finally decided to hunt down the evil one last time.

Six college students take a wrong turn and find themselves lost in a strangely deserted rural town... only to discover that this deceptively quiet place hides a murderous cult of children controlled by evil forces! Yet even as bodies begin cropping up all around them, the young friends decide to stay and rescue the children... or die trying!

Chucky hooks up with another murderous doll, the bridal gown-clad Tiffany, for a Route 66 murder spree with their unwitting hosts, two eloping high-school graduates.