While driving through the New Mexico Desert during a rainy night, the college students Jim Halsey and his girlfriend Grace Andrews give a ride to the hitchhiker John Ryder. While in their car, the stranger proves to be a psychopath threatening the young couple with a knife, but Jim succeeds to throw him out of the car on the road. On the next morning, the young couple sees John in another car with a family, and while trying to advise the driver that the man is dangerous, they have an accident. While walking on the road, they find the whole family stabbed in the car, and John sees that the driver is still alive. He drives to a restaurant seeking for help, but the police blame Jim and Grace to the murder and send them to the police station. However, John kills the policemen and pursues the couple, playing a tragic and violent mouse and cat game with Grace and Jim.

Innocent lives hang on the whim of an elusive psychopathic murderer whose strange riddles and impossible timelines force three people into a mission to end the game before one or all of them die.

In the 70's, the boy Billy is born with yellow skin due to a lever disease and his dysfunctional mother rejects him. Later he witnesses his mother and her lover killing his beloved father and burying him in the basement of their house, and he is locked in the attic alone along his childhood. When he is a teenager, he is sexually abused by his mother and she has a baby girl called Agnes. During Christmas, the deranged Billy escapes from his imprisonment, kills his mother and stepfather and blinds one eye of Agnes. He is declared insane and his sister is sent to an orphanage. In the present days, Billy escapes from the Clark Sanatorium to spend Christmas with his family. Meanwhile, his former house is the Delta Alpha Kappa sorority house in the campus of the Clement University, and the housemother and the sisters Kelli Presley, Dana, Lauren Hannon, Megan, Heather, Megan Helms, Melissa...

Laura's expecting. Her husband, Steven's a loving guy but has little time for her. Her mom lives thousands of miles away. Forced to give up on her dreams, she's always been a bit edgy. A C-section drives her over the edge, making her see things in a different light. A creepy babysitter doesn't make things any better. She begins seeing things, trusts no one, as she goes into self-destruct mode.

On the day after his fortieth birthday, the family man and computer analyst George Grieves goes to the Mt. Abaddon Hospital for a routine procedure of colonoscopy with Dr. Sharazi. Along his birthday party, his friends and family tell many cases of medical errors, and George is worried about. After the surgery, George finds that his surgery had complications because of a homonymous patient, and he had received a thoracoscopic sympathectomy instead. While interned, George discloses bizarre and dark secrets about the East Wing of the hospital while his wife and family have to take a decision about his fate.