Harry Penderecki, a once heralded horror auteur, finds himself on the outside looking in at Hollywood. He hasn't had a hit film in years, and most in the industry, including his close friends, think he's washed up. Harry is given one last chance to redeem himself with what could be his best or last picture. Brutal Massacre becomes just that, as the cast and crew find themselves battling one mishap after another as Harry struggles to keep his sanity against overwhelming resistance to finish the picture and find himself at the top once again.

With a pocketful of drugs, Nick West takes out his girlfriend Sammy, for a good time. When they explore an abandoned asylum, the discovery of a bizarre device, a cross between an electric chair and sadistic fetish machine, transforms drugged-out bliss into agony and despair. After Sammy is brutally assaulted and murdered by unseen forces, Nick becomes the number-one suspect. Years pass and Nick, who had been locked up in a mental hospital, is released into the care of eminent psychiatrist Dr. Willard, who is hell-bent on exposing the truth behind the killing. Accompanied by Dr. Willard and several of his students, Nick returns to the scene of the crime. However, the decrepit asylum hides a blood-drenched secret.

A plane crashes in the jungle. One of the survivors gets lost and while trying to find a way out of the jungle he gets captured by cannibals. He is humiliated, stripped naked, and thrown in a hole with a bird for a while. Eventually, he escapes with the help of a cannibal girl and tries to find his plane so he can go home.

At a Thai hospital, a doctor and his seven nubile nurses engage in the sale of bodies. Jealousy causes Tawan, one of the nurses, to threaten to blow the whistle on the practice, so the others murder her. The dealer in bodies doesn't arrange for delivery of Tawan's corpse for a full week. As midnight approaches on the seventh day after the murder, each of the remaining nurses as well as Dr. Taa, faces a supernatural revenger. In flashbacks we see the events leading up to the murder and realize the full range of relationships among the main characters, including the duplicitous Dr. Taa and Tawan's sister, Nook.

As a child Jack Brooks witnessed the brutal murder of his family. Now a young man he struggles with a pestering girlfriend, therapy sessions that resolve nothing, and night classes that barely hold his interest. After unleashing an ancient curse, Jack's Professor undergoes a transformation into something not-quite- human, and Jack is forced to confront some old demons... along with a few new ones.

A couple, lost in thick fog, take refuge in an old mansion next to a cemetery. Strange things start to happen.

A terrified man runs down a street, followed by something hidden in the darkness. He slams the door to his home, believing his is safe - but doors can't keep this horror out. A ghoulish apparition suddenly appears, killing him in a most horrific way Sammy and Tom are paranormal investigators, trying to solve a case that has haunted Tom for years. Every year, he comes to Germany - and every year, he leaves empty-handed. This year, however, they run into Donnie, an old friend who informs them of an unsolved mystery that's right up their alley. Donnie's American friend Sarah has been having nightmares. Her sister was brutally murdered and voices from beyond have drawn her to Germany, where she believes the answers must lie. Teaming up with Sammy and Tom, the group tries to seek out answers to the murder - and the ghoulish deaths that are befalling citizens of this small German town...