A couple en route from Las Vegas are forced to deal with a body out in the desert making their honeymoon one hellish ride.

Nathan, a brilliant New York lawyer who leads a life of professional success, but his private life is pretty dismal since he divorced Claire, his only love. Until he meets Doctor Kay, a mysterious doctor who introduces himself as a "Messenger." He claims that he can sense when certain people are about to die, and that he is sent to help them put their life in order before it's too late. Nathan doesn't believe a word of this, but soon afterwards he witnesses some disconcerting scenes which seem to confirm the doctor's claims.

New York postal worker Jacob Singer is trying to keep his frayed life from unraveling. His days are increasingly being invaded by flashbacks to his first marriage, his now-dead son, and his tour of duty in Vietnam. Athough his new wife tries to help Jacob keep his grip on sanity, the line between reality and delusion is steadily growing more and more uncertain.

After receiving mysterious empty packages inside his apartment, a young computer-programmer (named Simon) begins a personal investigation into their origins. This leads him to discover his odd and eccentric neighbors; an artificially intelligent robot-head, named Adam; a virtual-reality sex game; and a possible corporate conspiracy. As the story progresses, Simon's grip on reality becomes more and more tenuous, while his craving for Nature Fresh milk becomes almost unbearable. Is it all just in his mind, or is something more sinister happening here?

The head of the Green Manors mental asylum Dr. Murchison is retiring to be replaced by Dr. Edwardes, a famous psychiatrist. Edwardes arrives and is immediately attracted to the beautiful but cold Dr. Constance Petersen. However, it soon becomes apparent that Dr. Edwardes is in fact a paranoid amnesiac impostor. He goes on the run with Constance who tries to help his condition and solve the mystery of what happened to the real Dr. Edwardes.