It's turn of the century America when Andrew and Veronica first meet - by crashing into each other. They develop an instant and mutual dislike which intensifies when, later on, Andrew is forced to hire Veronica as a saleslady at Oberkugen's music store. What the two don't know is that while they may argue and fight constantly throughout the day, they are actually engaged in an innocent, romantic and completely anonymous relationship by night, through the post office.

Successful and well-liked, Dr. Noah Praetorius becomes the victim of a witch hunt at the hands of Professor Elwell, who disdains Praetorius's unorthodox medical views and also questions his relationship with the mysterious, ever-present Mr. Shunderson. Fuel is added to the fire when Praetorius befriends young Deborah Higgins, who has become suicidal at the prospect of having a baby by her ex boyfriend, a military reservist who was called up for service in the Korean War and killed in action.

Charlie Mason and Rusty Fleming are star reporters on a Chicago tabloid who are romantically involved as well. Although skilled in ferreting out great stories, they often behave in an unprofessional and immature manner. After their shenanigans cause their frustrated city editor to resign, the publisher promotes Charlie to the job, a decision based on the premise that only a slacker would be able crack down on other shirkers and underachievers. His pomposity soon alienates most of his co-workers and causes Rusty to move to New York. Charlie resigns and along with gangster friend Smiles Benson tries to win Rusty back before she marries a stuffy society author.

An artist has an opportunity to go to Paris and wants to bring his fiancee along. However, she's a psychiatrist who currently has three female patients who don't like men. So, he guises himself as three different men to gauge their trust and hopefully cure them so that his fiancee can go with him.

Tiffani and her friend Casey try to lure the gorgeous Zack with a phony online profile using the image of Tiffani's buff ex, Ryan... which works fine until the real Ryan shows up. Only through some fancy footwork, advice from his Aunt Helen and mentor Harry, and a daring sexual escapade can Casey figure out how to set things right and perhaps even find the love he's been seeking.

Two lost souls: she a con-artist in L.A.; he a puppeteer in San Antonio have the same dream linking each with the other. He travels to L.A. to find this woman he has become obsessed with. She resists, afraid of his kooky ideas until she travels with him to San Antonio and meets his wise grandmother. Story of two disparate people linked by "fate" gets increasingly interesting as it rolls along.