Adrienne Willis, a woman with her life in chaos, retreats to the tiny coastal town of Rodanthe, in the Outer Banks of North Carolina, to tend to a friend's inn for the weekend. Here she hopes to find the tranquility she so desperately needs to rethink the conflicts surrounding her -- a wayward husband who has asked to come home, and a teen-aged daughter who resents her every decision. Almost as soon as Adrienne gets to Rodanthe, a major storm is forecast and a guest named Dr. Paul Flanner arrive. The only guest at the inn, Flanner is not on a weekend escape but rather is there to face his own crisis of conscience. Now, with the storm closing in, the two turn to each other for comfort and, in one magical weekend, set in motion a life-changing romance that will resonate throughout the rest of their lives.

Zack and Miri are two lifelong platonic friends who make an adult film to pay the rent of their apartment. With their friend Delaney, the couple set out for auditionees for their porn film, but in the process of filming, they realize they feel more for each other than they had before.

In Albany, the marriage of Caleb end Catherine Holt is in crisis and they decide to divorce. However, Caleb's father, John, proposes that his son delays their separation process for forty days and follow a procedure called "The Love Dare" to make them love each other again.

Bertram Pincus is a man whose people skills leave much to be desired. When Pincus dies unexpectedly, but is miraculously revived after seven minutes, he wakes up to discover that he now has the annoying ability to see ghosts. Even worse, they all want something from him, particularly Frank Herlihy who pesters him into breaking up the impending marriage of his widow Gwen. That puts Pincus squarely in the middle of a triangle with spirited result.