In 2079, in Washington, the ex-CIA Operative Snow is brutally interrogated, accused of treason against the United States. The chief of the secret service Scott Langral believes that he shot the agent Frank in a hotel room. Meanwhile, the idealistic daughter of the president of the USA, Emilie Warnock, is visiting MS One, a maximum security prison in outer space expecting to find evidences that the prisoners are actually guinea pigs of a huge corporation. When one of her bodyguards loses a hidden...

In the year 2044, a man working for a group of killers called "Loopers" (they work for the mob and kill people who are sent blindfolded back in time from the year 2074 by their bosses) recognizes a victim as himself. He hesitates resulting in the escape of his older self.

For a factory worker named Douglas Quaid, even though he's got a beautiful wife who he loves, the mind-trip sounds like the perfect vacation from his frustrating life - real memories of life as a super-spy might be just what he needs. But when the procedure goes horribly wrong, Quaid becomes a hunted man as he finds himself on the run from the police.