A group of mountain climbers disappears while climbing the Himalayas in the 1950s. In the present, another group takes the same route and also disappears. A shady rich man hires a professional mountaineer and some scientists to find them.

In Point Pleasant, land of the legend The Mothman, a group of seven teenage friends accidentally kills the boy Jamie (Alex Hardee) in a prank by the river and they decide to cover up the incident. Ten years later, the journalist of the Washington Weekly Katharine Grant, who was one of the seven teenagers, is assigned by her editor to return to her hometown to prepare a matter about the 10th Mothman Festival. She meets with the other six friends that have stayed in the town and sooner they are murdered one by one by The Mothman. Katherine and her former boyfriend Derek seek help with old blind man Frank Waverly that has been luring The Mothman for many years trying to save their lives from the punishment of the entity.

In Los Angeles, the police put a residential building in quarantine. Meanwhile, the flight attendants of Trans Sky Air, Jenny and Paula, are welcoming the passengers of flight TS Air 318 from Los Angeles to Kansas City with Captain Forrest and Co-Pilot Wilsy. Teacher Henry brings a cage of hamsters to the cabin, but Jenny tells him that it should be transported in the cargo hold. However, one hamster bites the fingertip of the fat passenger Ralph. Soon, Ralph vomits and becomes aggressive, attacking Paula. The male passengers help Jenny and lock Ralph in the bathroom while Captain Forrest requests an emergency landing. When they land in the airport, they find all the gates closed and the Captain heads the plane to an abandoned terminal. Employee Ed helps the crew and passengers to reach the exit, but they find that they are closed. Soon they discover that the place is in quarantine and there is no way out.

An English anthropologist has discovered a frozen monster in the frozen wastes of Manchuria which he believes may be the Missing Link. He brings the creature back to Europe aboard a trans-Siberian express, but during the trip the monster thaws out and starts to butcher the passengers one by one.

Zebraman awakens 15 years in the future, unclear on what has happened to him, and quickly discovers that the evil Zebra Queen has a hold on Tokyo.

An atomic explosion awakens Gammera--a giant, fire-breathing turtle monster--from his millions of years of hibernation. Enraged at being roused from such a sound sleep, he takes it out on Tokyo.

High school student Ling Xiaoyu is recruited by Anna Williams of G Corporation to transfer to Kyoto University and gather information on a student named Shin Kamiya. Meanwhile, Jin Kazama, the current head of the Mishima Zaibatsu, sends Alisa Bosconovitch to the university for the same mission. Though they do not know each other's true motives, Xiaoyu and Alisa become close friends. However, their friendship is put to the test when Shin is captured by an unknown assailant.

Six college friends find themselves caught up in a cat and mouse hunt with a race of creatures who possess the ability to transform into anything from which it has consumed DNA.