In a world ravaged by disease, he's the only cure... and the last hope for human-kind.

In the year 3028 A.D., Earth is being attacked by the Drej, which are aliens made of pure energy! The Drej mother-ship destroys Earth with an energy beam just as hundreds of space vehicles manage to escape with the last of mankind aboard! One of the escapees is Sam's young son Cale, who carries with him a ring given to him by his father. Fifteen years later, Cale works on a salvage station, eking out a rough life and hating his father for having disappeared aboard the Titan so long ago. Without a home planet, surviving humans have been reduced to outer space drifters and are constantly bullied and looked down on by other space-faring races. A human captain named Joseph Korso and his pilot Akima seek out Cale and explain that he must help them find the Titan which contains a mechanism that will create a new Earth and therefore unite all of humanity. Meanwhile, the Drej wants to find the Titan so that they can destroy it...

Over one hundred years ago, a cataclysmic chain of events plummeted the earth into the dark ages which destroyed most of civilization, and the remaining few survivors attempt to change the course of events that led to the destruction.

When a mysterious storm kills all but one crew member of the first manned mission to mars, a rescue mission is launched. Once on the red planet, the crew finds the sole survivor of the first mission who informs them that this was no ordinary storm. It was meant to protect something. But what?