The hacker Josh invades the computer of Douglas Ziegler, who is developing a powerful wireless signal, and accidentally releases a mysterious force that takes the will to live of human beings, generating a suicide epidemic and increasing the force. His girlfriend and student of psychology, Mattie, sees each one of their common friends die and the destruction of the modern world, and together with her new acquaintance Dexter, they try to plan a virus developed by Josh in the network to shutdown the system and save mankind.

In New York, when the shy and lonely project manager of a design firm Matt Saunders meets Jenny Johnson in the subway, he invites her to date and have dinner with him. Jenny immediately falls in love for him, they have sex and she discloses her true identity to him, telling that she is the powerful superhero G-Girl. After meeting his co-worker and friend Hannah Lewis, the needy Jenny becomes jealous, controlling and manipulative, and Matt follows the advice of his best friend Vaughn Haige and dumps her, breaking her heart. Jenny turns Matt's life into hell, while he has a romance with Hannah. However, the archenemy of G-Girl and former high school sweetheart of Jenny, Professor Bedlam, proposes Matt to lure Jenny to strip her superpowers.

A city is ravaged by an epidemic of instant "white blindness". Those first afflicted are quarantined by the authorities in an abandoned mental hospital where the newly created "society of the blind" quickly breaks down. Criminals and the physically powerful prey upon the weak, hoarding the meager food rations and committing horrific acts. There is however one eyewitness to the nightmare. A woman whose sight is unaffected by the plague follows her afflicted husband to quarantine. There, keeping her sight a secret, she guides seven strangers who have become, in essence, a family. She leads them out of quarantine and onto the ravaged streets of the city, which has seen all vestiges of civilization crumble.