Four individuals sign up for a psychological research study only to discover that they are now subjects of a brutal, classified government program.

Siblings, Brad and Lisa Carpenter, along with two lifelong family friends, Will and Vanessa, set out road-tripping to an annual family reunion. They make the decision to find a place to stop and camp for the night. What ensues is a violent disturbance by six masked assailants, without motive or reason. The group find themselves living a night of psychological games and physical terror, and as morning dawns; the reality of what will come is more terrifying than anything the group could have ever imagined.

Upon moving to Britain to get away from American violence, astrophysicist David Sumner and his wife Amy are bullied and taken advantage of by the locals hired to do construction. When David finally takes a stand it escalates quickly into a bloody battle as the locals assault his house.

High school seniors Nathan and Karen find a website with photos of children who are missing or believed abducted. One of the photos is of Nathan as a child, putting into question the identities of the couple whom he's always called Mom and Dad. Contacting the site to learn more only results in Nathan becoming the target of an intense, high-tech, international manhunt. Before his "parents" can explain themselves, they are executed by hired guns, and Nathan is on the run with Karen in tow (who just happened to be there at the wrong time). Phone use by either of them only connects directly to a man claiming to be C.I.A., in whom they find reasons not to trust. With encroaching shootouts, car chases, hand-to-hand combat and explosions around them, this seems quite much for a mere case of child abduction, and Nathan can only rely on the wrestling, boxing and martial arts skills taught by his "dad" to protect both himself and Karen as they follow a lead to find Martin, Nathan's biological ...