A group of college students visit a secluded vacation home to celebrate their upcoming graduation. The fun doesn't last long when a sadistic psychopath forces them to participate in his deadly contest. The rules are simple -- in order to survive they must kill each other. As tension builds, and relationships begin to crumble, they realize that only one can make it out alive. Could you trust your boyfriend? Your girlfriend? Your best friend? Only one can go home. So who will be the last man or woman standing?

Gibson Rickenbacker is a hired fighter living in a plague-ravaged apocalyptic America where a plague has infested most of the United States and the rest of the world. In New York City, Gibson encounters a woman named Pearl Prophet. Pearl reveals to Gibson that she is a cyborg who is carrying vital-information for a group of scientists in Atlanta who are working on a cure to the plague and Pearl hires Gibson to escort her back to Atlanta. But Pearl is kidnapped by "Pirates" a murderous gang led by Fender Tremolo, who wants the cure for themselves and they decide to take Pearl to Atlanta themselves. Gibson, joined by a young woman named Nady Simmons, goes in pursuit of Fender and his gang, as Gibson sets out to rescue Pearl, stop Fender and his gang from reaching Atlanta and defeat Fender who slaughtered Gibson's family.

Manipulative police lieutenant Phoebe McNamara is a success as hostage negotiator, but drove ex-husband Roy squires away, so she and their toddler daughter Carly live with her devoted ma Essie. Systematic self-righteous verbal abuse of uniformed cops leads to a grim feud with one of them, cocky Arnie Meeks. Captain David McVee and businessman-philanthropist Duncan Swift, her patient lover, side with her and the assumption Meeks is behind a violence wave targeting her, but that proves dead-wrong.

The small island resort town of Amity is trying to bounce back from the financial problems it had after becoming known as the site of shark attacks four years ago. Mayor Larry Vaughn is welcoming developer Len Peterson and his new resort to Amity. Two scuba divers are exploring the area where the Orca sank after police chief Martin Brody killed a huge shark four years ago. A shark shows up and kills the two divers, but not before one of the divers takes a close-up picture of the shark's eye, and sometime later, while a mother is driving a boat that's pulling her water-skiing teenage daughter, the shark kills the daughter and causes the mother to accidentally blow up the boat, then a killer whale is found on the shore with a huge bite on it. After Brody sees this, he knows there's another huge great white shark in Amity's waters, but Vaughn and Peterson explain these attacks away as non-shark accidents...