Robert Neville, a doctor, due to an experimental vaccine, is the only survivor of an apocalyptic war waged with biological weapons. The plague caused by the war has killed everyone else except for a few hundred deformed, nocturnal people calling themselves "The Family". The plague has caused them to become sensitive to light, as well as homicidally psychotic. They believe science and technology to be the cause of the war and their punishment, and Neville, as the last symbol of science, the old world, and a "user of the wheel", must die. Neville, using electricity, machinery, and science attempts to hold them at bay.

While traveling through the desert for an appointment with a client, the businessman David Mann from California passes a slow and old tanker truck. The psychotic truck driver feels offended and chases David along the empty highway trying to kill him.

As Aunt Alice, Ruth Gordon applies for the job of housekeeper in the Tucson, Arizona home of widow Claire...

Cowboy James Franciscus seeks fame and fortune by capturing a Tyrannosaurus Rex living in the Forbidden Valley and putting it in a Mexican circus. His victim, called the Gwangi, turns out to have an aversion to being shown in public. Another film featuring the stop-action special effects talents of Ray Harryhausen.

The professional mercenary Sir William Walker instigates a slave revolt on the Caribbean island of Queimada...