Frank Castle, the ex-military man whose family was killed by criminals, who became a vigilante known as the Punisher, goes after a whole mob family and gets everyone except enforcer Billy Russoti. He tracks Russoti down and chases him into a vat that is used for crushing bottles. Frank turns on the crusher hoping it would take care of him but it doesn't. He survives but sustains very severe injuries that even with plastic surgery his face looks like a jigsaw puzzle. So he decides to adopt the name Jigsaw. Frank who killed one of Russoti's people who unknown to him is an undercover Fed, decides to pack it in. But when he learns Russoti didn't die and is looking for the money he entrusted to the Fed and will go looking for it at his home which means his family is in danger. So Frank tries to save them. But Russoti wants revenge on Frank so he breaks out his brother who is so crazed that he is committed to an asylum...

Barkley Michaelson is in a deep life rut. He's struggling to finish his PhD thesis when his father, the learned Eli Michaelson, wins the Nobel Prize for Chemistry. Barkley and his mother, Sarah, a renowned forensic psychiatrist, now have the ill-fortune of living with a man-eating monster whose philandering ways have gotten less and less discrete. As if Barkley's world is not bad enough, on the eve of his father receiving the Nobel, Barkley is kidnapped and the requested ransom is the $2,000,000 in Nobel prize money. Needless to say, Eli refuses to pay it and so starts a venomous tale of familial dysfunction, lust, betrayal and ultimately revenge. In the words of Michel De Montaigne, the 16th century philosopher: "There is more barbarity in eating a man alive than in eating him dead."

Lt. Dave Robicheaux, a detective in New Iberia, Louisiana, is trying to link the murder of a local hooker to New Orleans mobster Julie (Baby Feet) Balboni, who is co-producer of a Civil War film. At the same time, after Elrod Sykes, the star of the film, reports finding another corpse in the Atchafalaya Swamp near the movie set, Robicheaux starts another investigation, believing the corpse to be the remains of a black man who he saw being murdered 35 years before.

Molly Hartley looks to put her troubled past behind her with a fresh start at a new school, where she sparks with one of the most popular students. But can her secrets stay buried, especially as she learns more about the horrific truth that awaits her once she turns 18?