The next door neighbors Nell Bedworth and Woody Deane have opposite behaviors and hate each other: the virgin geek Nell is polite, sensitive and well-prepared to go to Yale, while Woody is rude and his greatest expectation is to join a mediocre university due to his abilities playing football. When Nell and Woody are assigned to visit a museum together, they argue in front of a statue of an Aztec god. During the night, their souls swap bodies, bringing difficult situations to them. They first try to damage each others reputation in high school, but soon they discover that their dream of joining college can only happen with mutual respect and support.

18th century justice catches up with a pair of grave robbers. With only a few hours to go before his date with the guillotine, Arthur Blake tells his life story to Father Francis Duffy. Before long, Arthur spills the beans on how he got started in the grim corpse peddling business with seasoned ghoul Willie Grimes.

Young poetess Rose Elliot buys a book from a local antique dealer, a diary in Latin of an architect, E. Varelli. She learns of the Three Mothers, and believes her apartment building is one of their houses. She pleads her brother Mark, who is studying musicology in Rome, to come, because she is afraid. Mark's friend Sara reads her letter, which he left behind in class, and discovers the school is run by the Mater Lacrimarum, and is killed for this knowledge. The house of Mater Suspiriorum has already been destroyed, and by the time Mark arrives in New York City, he is investigating his sister's murder.

Eddie Lomax (Van Damme) is a vetern soldier sick of life, wandering the desert looking for a reason to die. An incident with a few thugs from the nearby town who steal Eddies motorbike and beat him almost to death, starts in Eddie a flame for revenge. Helped by Mr. Early, and some other good fellows, Eddie is out for vengeance.

When a drug deal turns into a bloodbath, a junkie-gangster crosses paths with an illegal alien. The illegal alien ends up with the gangster's ID and uses it to create a new successful life as a US citizen. A near death experience causes the gangster to re-evaluate his life, and when he leaves prison three years later, he is clean, sober, and ready to put his life back together. But both men are haunted by their pasts and they are soon set on a collision course that may destroy them and the women they love.

Shayla Stonefeather, a Native American attorney prosecuting a Lakota teen in a controversial murder trial, returns to the reservation to say goodbye to her dying father. After the teen is killed, she hears ghostly voices and sees strange visions that cause her to re-examine beliefs she thought she left behind.

"I Got Five On It Too" continues the hilarious adventures of Barney Bumble and the gang and their "high times." As the guys plan a house party complete with liquor, girls and weed, their "best bud" Barney Bumble gets set-up by his new rival Larry Poppins and gets busted by the cops for selling marijuana, Jimmy, Oscar and Arnie have to come to the rescue and get some payback against the new neighborhood drug dealer who's been trying to move in on Barney's turf.

In contemporary Prague a young musician is obsessed by jealousy for his beautiful girlfriend Klara. He engages a private detective to spy on Klara but this starts an uncontrollable series of accidents, misunderstandings and traps culminating in an unusual Venice.