Feeling trapped in the stifling, wealthy enclave of Westport, Connecticut, Anders Hill (Ben Mendelsohn) retires from his job in finance and leaves his wife (Edie Falco) in the hopes that it will renew his lust for life. However, he's quickly faced with the startling reality of his choices; he spends his days looking for things to decorate his empty shelves, sleeping with strangers and feeling terribly lost. Missing his ex-wife and on the outs with his troubled 27-year-old son (Thomas Mann), Anders befriends a drug-addicted teen (Charlie Tahan), sending him down a path of reckless and regrettable behavior. His shameful actions cause him to question who he is as a father and, ultimately, who he is as a person.

Teenagers Zach and Josh have been best friends their whole lives, but when a gruesome accident leads to a cover-up, the secret drives a wedge between them and propels them down a rabbit hole of escalating paranoia and violence.

A dachshund passes from oddball owner to oddball owner, whose radically dysfunctional lives are all impacted by the pooch.

A couple who keeps their sick son in a secluded environment find their controlled lives challenged by a young girl who moves in next door.

After nearly four decades together, Ben (John Lithgow) and George (Alfred Molina) finally tie the knot in an idyllic wedding ceremony in lower Manhattan. But when George loses his job soon after, the couple must sell their apartment and - victims of the relentless New York City real estate market - temporarily live apart until they can find an affordable new home. While George moves in with two cops (Cheyenne Jackson and Manny Perez) who live down stairs, Ben lands in Brooklyn with his nephew (Darren Burrows), his wife (Marisa Tomei), and their temperamental teenage son (Charlie Tahan), with whom Ben shares a bunk bed. While struggling with the pain of separation, Ben and George are further challenged by the intergenerational tensions and capricious family dynamics of their new living arrangements.

Charlie St. Cloud is a young man overcome by grief at the death of his younger brother. So much so that he takes a job as caretaker of the cemetery in which his brother is buried. Charlie has a special lasting bond with his brother though, as he can see him. Charlie meets up with his brother (Sam) each night to play catch and talk. Then, a girl comes into Charlie's life and he must choose between keeping a promise he made to Sam, or going after the girl he loves

In Manhattan, twenty-two year-old Harvard lawyer Emilia Greenleaf has a crush on her boss, Jack Woolf, and they have an affair. Jack's marriage is a sham but his son, William, is his pride and joy. Emilia soon discovers she's pregnant, and Jack divorces his wife, Carolyn, in order to marry her. His son is poisoned against the partnership by his mother, and resented by his stepmother. Emilia, who has issues with her womanizer father, delivers Isabel but the baby dies. The marriage begins to suffer and William unexpectedly steps in to help.

Small-town detective Noah Cordin is called to solve a juvenile homicide that occurred during a home burglary in his affluent town of Hilliard. The dead boy's mother, Allison Connor, is a member of the Meskada County Board of Commissioners, and a powerful woman in Hilliard; and the entire township rallies together in solidarity - to support her and Detective Cordin's efforts to find the killers.

In Montgomery County, Kelly Taylor is ready to go to college and takes her autistic brother, Tom, to a specialized institution. However, the bank informs her that she does not have sufficient funds in her account to honor her check. Her stepfather, Johnny Gaveneau, withdrew the money from her account the day before. When Kelly arrives home, Johnny reveals that he used the money to buy a tiger for his 'safari show' project. In addition he has the house reinforced, in order to protect it from hurricanes, so all the windows and external doors are covered with wood. When Kelly awakes, she finds that the starving tiger is inside the house and Tom and she are trapped with the ravenous animal.

Adrienne Willis, a woman with her life in chaos, retreats to the tiny coastal town of Rodanthe, in the Outer Banks of North Carolina, to tend to a friend's inn for the weekend. Here she hopes to find the tranquility she so desperately needs to rethink the conflicts surrounding her -- a wayward husband who has asked to come home, and a teen-aged daughter who resents her every decision. Almost as soon as Adrienne gets to Rodanthe, a major storm is forecast and a guest named Dr. Paul Flanner arrive. The only guest at the inn, Flanner is not on a weekend escape but rather is there to face his own crisis of conscience. Now, with the storm closing in, the two turn to each other for comfort and, in one magical weekend, set in motion a life-changing romance that will resonate throughout the rest of their lives.