Ben Bingham has slipped into a fossilized middle-age, unlike his vibrant wife Amanda. When she finally leaves him, Ben is at a loss. He drowns himself in gin and refuses to get out of his pajamas until his popular 17 year-old son Justin takes over. He changes Ben's "look" and pushes him out into the social scene. Before Ben knows what is happening, he is the most popular single man in town, pursued by his nurse, his trainer, and karaoke-singing twins. Things change when Justin falls in love for the first time and now finds his father's lifestyle incredibly superficial. Ben is forced to refocus, recapture his humanity, his heart, and most importantly his wife... who is now with another man.

Joe comes from Iowa to New York and, being short of money, wants to find an apartment with very low rent. His quest is successful, but he must share the residence with some 50,000 cockroaches. The insects turn out to be Joe's best friends.

Out in California's San Fernando Valley, Isabel is trying to reinvent herself. A naïve, good-natured witch, she is determined to disavow her supernatural powers and lead a normal life. At the same time, across town, Jack Wyatt a tall, charming actor is trying to get his career back on track. He sets his sights on an updated version of the beloved 1960s situation comedy Bewitched, re-conceived as a starring vehicle for himself in the role of the mere-mortal Darrin. Fate steps in when Jack accidentally runs into Isabel. He is immediately attracted to her and her nose, which bears an uncanny resemblance to the nose of Elizabeth Montgomery, who played Samantha in the original TV version of Bewitched. He becomes convinced she could play the witch Samantha in his new series. Isabel is also taken with Jack, seeing him as the quintessential mortal man with whom she can settle down and lead the normal life she so desires...

A spaceship shaped like a human lands face first on Liberty Island. Its crew (of tiny, intelligent, and unemotional beings) is looking for an orb sent from its planet to extract the oceans' salt, which will ruin Earth. The orb is in the possession of Josh, the fifth-grade son of a single mom whose car strikes the ambulatory alien spaceship and cripples its power supply. The crew has 48 hours to recover the orb, throw it in the Atlantic, and leave Earth. Over the course of two days, the ship's crew experiences chaos and emotion in New York. Do Earth's giants - Josh and his mom - have anything to teach these brainy aliens? Meanwhile, mutiny is afoot and the cops are closing in.