This offbeat dark comedy take place when four friends (Brisco, J Rob, Pedro, and Hay Love) have a backyard bar-b-q and decide to come up on some bud. Not knowing where to turn, because the streets have been dry for a few months, they end up scoring from the son of a over protective mob figure by the name of Fredrico, who vows, if anything should happen to his son, their will be hell to pay. After a tragic accident, the four friends are on the run with only one person to turn to, Krego, Brisco's long time friend. Krego confirms to them, Fredrico is a very powerful man, and there is no escaping his fury. Their only option is to change their appearance through underground plastic surgery, which would take them on a five hundred mile road trip. Along the way, they will have to avoid Fredrico's beautiful assassin, Venus, and other unsavory characters, leaving them to ponder the question, was it just dumb luck, or was it the bud?

Life is laid bare as a group of plane crash survivors find themselves stranded on a remote Pacific island. The trauma of the crash soon becomes overshadowed by the island itself, where unseen creatures stalk the jungle, paranormal happenings abound and astonishing coincidences reveal themselves. In this unique environment emotions swell as the survivors battle their inner and outer demons, and strive to live together - so that they won't die alone.

In Cayman Island, the daughter of a powerful man - Andrea - and the fisherman Shy are in a deep but secret love, hidden from Andrea's parents. When Andrea's father sails in a fish-trip, they have a night of love at Andrea's home; however they sleep and are surprised by the arrival of her family in the morning. Later, Andrea's brother Hammer throws acid on the face of Shy and spends four months in prison. In Miami, the dirty businessman Carl Ridley is chased by Federal agents and escapes with his teenage daughter Pippa to Cayman Island trying to reach his lawyer Mr. Allen. Pippa meets the small time thief Fritz sleeping in her room and he invites her to go a party. Before leaving the condo, Fritz sees Carl counting lots of money. Fritz owes money to the dangerous drug dealer Richie Rich and tells him about the fortune Carl has. Along a Friday 13th night, their lives entwine in a chain of tragic events.

After total humiliation at her thirteenth birthday party, Jenna Rink wants to just hide until she's thirty. Thanks to some wishing dust, Jenna's prayer has been answered. With a knockout body, a dream apartment, a fabulous wardrobe, an athlete boyfriend, a dream job, and superstar friends, this can't be a better life. Unfortunetly, Jenna realizes that this is not what she wanted. The only one that she needs is her childhood best friend, Matt, a boy that she thought destroyed her party. But when she finds him, he's a grown up, and not the same person that she knew.

Henry Roth is a man afraid of commitment up until he meets the beautiful Lucy. They hit it off and Henry think he's finally found the girl of his dreams, until he discovers she has short-term memory loss and forgets him the very next day.

One day California wakes up and not a single Latino is left in the state. They have all inexplicably dissappeared, chaos, tragedy, and comedy quickly ensue.