In Manhattan, the successful executive Jack is a methodical and controlled man with simple habits that works in an advertisement agency with his coworker George. While smoking a cigarette on the roof of the building of the agency, Jack meets the aspirant actress Jill that has just arrived in New York and is seeking a job. He sympathizes with her situation and gives her name to a Klubendorf commercial in the campaign promoted by his agency. When he takes Jill home, he finds that she lives in a very low-budget hotel and out of the blue, he invites her to stay in the guest room of his fancy apartment for a while. Jill changes the behavior of Jack that becomes happier, and proposes Jack to write together a manifesto where the first rule is "be honest". However, she omits to Jack that she is sick with cystic fibrosis and she would have only a couple of years more. When Jack discovers that Jill is ill...

Some say that all houses have memories. For one man, his home is the place he would kill to forget. A family unknowingly moves into a home where several grisly murders were committed...only to find themselves the killer's next target. Successful publisher Will Atenton (Craig) quit a job in New York City to relocate his wife, Libby (Weisz), and two girls to a quaint New England town. But as they settle into their new life, they discover their perfect home was the murder scene of a mother and her children. And the entire city believes it was at the hands of the husband who survived. When Will investigates the tragedy, his only lead comes from Ann Paterson (Watts), a neighbor who was close to the family that died. As Will and Ann piece together the disturbing puzzle, they discover that the story of the last man to leave Will's dream house will be just as horrifying to the one who came next.

Boston, 2009. A police detective (Roddy Piper) searches for Adrian Dunn, his ex-partner (Billy Drago) who murdered his wife. Dunn has escaped from prison on the moon and returned to Earth with an alien virus.

Siblings, Brad and Lisa Carpenter, along with two lifelong family friends, Will and Vanessa, set out road-tripping to an annual family reunion. They make the decision to find a place to stop and camp for the night. What ensues is a violent disturbance by six masked assailants, without motive or reason. The group find themselves living a night of psychological games and physical terror, and as morning dawns; the reality of what will come is more terrifying than anything the group could have ever imagined.

Big city girl Caroline is new to a small town, she disregards her high school classmates, and then just for kicks starts a sexual relationship with her teacher, Mr. A. Meanwhile, there's a serial killer roaming the town, an industrial fire burning on the outskirts, and Thurston is mourning the loss of his best friend. As Thurston falls in love with Caroline, realities quickly catch up to all characters, and they are all going to have mature or face the consequences.