Former high school English teacher and famed mystery writer Jessica Fletcher has a gift for solving mysteries. You see, it seems murder follows her around, whether it be to the houses of her seemingly endless number of friends, nieces, and nephews or right in her hometown of Cabot Cove, Maine. Jessica is sometimes assisted by her friend Dr. Seth Hazlitt or the local sheriff, Amos Tupper (later Sheriff Metzger). Sometimes, later in the series, Jessica would only narrate the episode, which would be a dramatization of one of her novels. In later seasons, Jessica moved to New York City to be closer to her publisher and also closer to crime.

A desperate TV producer convinces an old Armenian Uncle to star in a new reality show. Cultures collide when Uncle Rafael is thrown into the Schumacher family household where he has one week to save a broken and dysfunctional American family from falling apart. The only rule-everyone must follow his rules.

The Munsters are a weird but honest family. Herman (the father) is Frankenstein's monster. Lily (his wife) and Grandpa (her father) are vampires. Eddie (their little son) is a werewolf. Marilyn (their niece) is the only normal one (that is the ugly duck of the family).

Levi Collins is set to go to the local University on a tennis scholarship, but he forgot to tell his parents one thing - he didn't graduate. As a result, he must take summer school before his mom and dad discover he's failed senior science. At school, Levi falls in love with his classmate, Katie, and learns that he has to make a choice between playing tennis and receiving a proper education. General Education is a quirky comedy about a family learning to grow together.

Balki Bartokomous, a sheepherder from the small Mediterranean Greek-like island of Mypos, travels to the United States in search of his relatives. He finds his cousin, Larry Appleton - who has recently 'escaped' from his large-sized family and is reveling in the unaccustomed luxury of having his own room to himself. They end up sharing accommodation in Larry's apartment - even though the two cousins could not be more dissimilar. For, while Larry is panicky, hyperventilative, business-like and mercenary - Balki is placid, unharried, sunny-natured and idealistic.

A singer-songwriter hits the road with a self-appointed music revolutionary.