When Connor Macleod sees his old friend Rachel die in an explosion, he's had it with his immortal life and the endless pain it brings him and those he loves. He locks himself inside the Sanctuary, a Watcher-organized retreat stationed on holy ground, where immortals who are tired of the game can go to forever escape it, as well as to ensure that The Prize never falls into the wrong hands. But when an old enemy, Jacob Kell, and his posse of assassins attack the Sanctuary and kill everyone there but Connor, he is forced out into the open and into battle. Kell and Connor were friends once, and knew each other back when Connor was cast from Glenfinnan; he returned when news came that his mother was to be burned at the stake, and in the attempt to free her, Kell was killed by none other than Connor himself, and became an immortal, bitter with hate, and devoted to making Connor's life a living hell...

When Henry DeTamble meets Clare Abshire in a Chicago library they both understand that he is a time traveller, but she she knows much more than this about him as he has not yet been to the times and places where they have met before. He falls in love with her, as she has already with him, but his continuing unavoidable absences time travelling - and then returning with increasing knowledge of their future - makes things ever more difficult for Clare.

Mima leaves the idol group CHAM, in order to pursue her dream as an actress. Mima climbs up the rocky road to success by performing as rape victims and posing nude for magazines, but is haunted by her reflections of the past.

This movie is a declaration of love to cinema that is used as a metaphor for the universe itself. We are the films and God is projecting them, including this one with Rachel and Leopoldo, who in a former life literally co-invented cinema as an assistant of named .