In Manhattan, when a client is bitten by a rat in the dressing room of the Garsons Department Store and contracts Weil's disease, the manager Susan Costello is assigned to hire and give all the necessary support to the best exterminator in New York, Jack Carver. The efficient Jack and his assistant Ty find a colony of mutant rats and try to convince the health department administrator and former partner of Jack, Ray Jarrett, how serious the infestation is. But the politician Ray is interested in covering the problem to protect economical interests of powerful groups.

Horror movie actor Paul Toombes, famous for playing "Dr. Death," suffers a nervous breakdown before going to England to do a TV series. Cast and crew members start dying the way characters did in Toombes' old movies.

Valentine's Day 1988: At the school dance, geeky Jeremy Melton bravely faces one rejection after the other when asking four popular girls to dance with him. A fifth girl, plump and insecure, agrees, but they end up making out under the bleachers. When a group of school bullies catches them, the girl claims that Jeremy attacked her. This causes them to strip off his clothes and beat him up in front of the entire school. Flash forward to 2001. We meet the five girls who were in that school gym: Kate, Paige, Shelly, Lily and the formerly plump Dorothy. They are all in their 20's now and trying to sort out their love lives, which is appropriate, since Valentine's Day is coming up. After a disastrous date with a loser, one of the girls, a pre-med student, is murdered by a Cherub-mask wearing killer who sent her a death threat in the form of a Valentine card prior to the attack...

When Frank and Julie move to a small isolated town with their son Sam, both Julie and Sam become ill. Driven by terrifying nightmares of torture that come true Frank begs a local midwife Helen to care for Sam as he desperately searches for a way to stop this curse on his family. When he discovers they are being tortured by the vengeful spirit of a child that was buried alive years earlier, Frank is pushed to the brink of madness as he tries to stop the ghost and save his dying family.

Detective Michael Turner investigates mysterious deaths that occur in and around a maximum-security prison. What begins as just another suicide and murder case unfolds into a furious struggle to uncover the unexplainable while escaping death at the hands of a vengeful spirit unleashed within the prison walls.

Some fishermen are attacked in the Louisiana swamps. When the word gets out of a mysterious Bigfoot-type creature, two researchers come to a small town to study and hopefully discover what the beast is. Their research from some farmers help the two men to learn that the creature may be a very angry and murderous missing link.

In Mexico, another vampire slayer, Derek Bliss, is hired by a shady priest and aided by a group of fellow slayers in finding a large nest of 'suckers' and their powerful leader, a vampire princess. She is seeking a legendary black crucifix - the same crucifix used unsuccessfully in the first movie to perform a ritual which will enable vampires to walk in sunlight and be invulnerable.

A group of five led by Julie set up their filming equipment in the hotel of the derelict town of Goldfield, hoping to capture footage of the ghost of Elisabeth Walker, a maid tortured and killed in room 109. Troubled by visions, Julie discovers that a necklace, handed down to her from her grandmother, is somehow connecting her to this tragedy.