In Mexico, another vampire slayer, Derek Bliss, is hired by a shady priest and aided by a group of fellow slayers in finding a large nest of 'suckers' and their powerful leader, a vampire princess. She is seeking a legendary black crucifix - the same crucifix used unsuccessfully in the first movie to perform a ritual which will enable vampires to walk in sunlight and be invulnerable.

A group of five led by Julie set up their filming equipment in the hotel of the derelict town of Goldfield, hoping to capture footage of the ghost of Elisabeth Walker, a maid tortured and killed in room 109. Troubled by visions, Julie discovers that a necklace, handed down to her from her grandmother, is somehow connecting her to this tragedy.

In a seaside Irish town, a widower sparks with a visiting horror novelist while he also begins to believe he is seeing ghosts.

In San Diego, Sarah Landon is invited by her grandmother's friend, Thelma Shaw, to spend the weekend with her in Pine Valley, California. Sarah used to spend vacations there during her childhood with her recently-deceased friend Megan. While heading to Pine Valley, her car breaks down and Carlos, the mechanic, calls his assistant, Matt Baker, to give her a ride. Sarah knows Matt from her childhood and asks about his older brother, David. Meanwhile Carlos tells a sad story about their uncle, Ben Woods. He apparently used to brag about his only son, Johnny, considered by Ben to be the best baseball player in the Valley. On his twenty-first birthday, Ben's sister Mary Ann Baker decided to celebrate with Johnny but she had a car accident and the teenager died. Ben promised to kill David Baker on his twenty-first birthday and he dies on the day of Johnny's funeral. Over the years...

Jimmy Lidell is a "nobody", stealing to earn a living in a dead-end life searching for his long lost girlfriend... until he meets Luc Tyer... a bigger-than-life underworld heavy that makes him an "offer he can't refuse". Jimmy accepts, but is leery about the secret motives behind Luc's willingness to teach the business. Jimmy's mother suspects that Jimmy may be running with the wrong crowd, but Jimmy turns a deaf ear to her religious warnings. Luc soon reveals his plans to use Jimmy as his unholy servant in a deadly and bloody game of evil revenge and power.

A young girl (Mary) and her family move into a new home along with her Grandmother. The Family have recently been recovering from the loss of their daughter (Jennifer). During the family's stay, They are attacked by the spirit of Jennifer, mostly taunting Mary. The family are subject to Mary being under the influence of Jennifer and are slowly picked off one by one.

This collection of David Lynch's short films cover the first 29 years of his career. Each film is given a special introduction by the director himself. His earliest underground films Six Figures Getting Sick (1966), The Alphabet (1968), The Grandmother (1970) and The Amputee (1974) are showcased as well as two requisitioned works well into his successful career The Cowboy and the Frenchman (1988) and his addition for Lumière and Company (1995).