The moon rises at a predestined angle and awakens the sleeping Dr. Phibes three years later. To his dismay, he finds his house has been demolished and his papyrus scrolls stolen, the scrolls he needs to find the Pharoah's Tomb in Egypt, where the River of Life flows. After identifying the source of the papyrus theft, he packs and leaves for Egypt with his assistant Vulnavia, still intent upon awakening his dead wife Victoria. The parties responsible for the theft of Phibes' scrolls suffer an attrition problem as Inspector Trout chases him across the world.

Actors led by Alan Ormsby go to a graveyard on a remote island to perform a necromantic ritual. The ritual works and soon the dead are walking about and chowing down on human flesh.

Robert Neville, a doctor, due to an experimental vaccine, is the only survivor of an apocalyptic war waged with biological weapons. The plague caused by the war has killed everyone else except for a few hundred deformed, nocturnal people calling themselves "The Family". The plague has caused them to become sensitive to light, as well as homicidally psychotic. They believe science and technology to be the cause of the war and their punishment, and Neville, as the last symbol of science, the old world, and a "user of the wheel", must die. Neville, using electricity, machinery, and science attempts to hold them at bay.

A doctor, scientist, organist, and biblical scholar, Dr. Anton Phibes, seeks revenge on the nine doctors he considers responsible for his wife's death.

As Aunt Alice, Ruth Gordon applies for the job of housekeeper in the Tucson, Arizona home of widow Claire...

The radiation from a fallen satellite might have caused the recently deceased to rise from the grave and seek the living to use as food. This is the situation that a group of people penned up in an old farmhouse must deal with.

Satan-worshiper Prince Prospero invites several dozen of the local nobility to his castle for protection against an oncoming plague, the Red Death. Prospero orders his guests to attend a masked ball and, amidst a general atmosphere of debauchery and depravity, notices the entry of a mysterious hooded stranger dressed all in red. Believing the figure to be his master, Satan, Prospero is horrified at the revelation of his true identity.